Sun
19
Apr
Amyotrophic Lateral Sclerosis (ALS)
Amyotrophic lateral sclerosis (ALS) is a progressive nervous system disorder. It gradually destroys the nerves responsible for muscle movement. Over time, ALS leads to total paralysis of muscle movement, including respiration.
Causes
The cause of ALS is not known, but it appears that genes may play a role in a very small number of cases.
Risk Factors
A risk factor is something that increases your chance of getting a disease or
condition.
- Having a family member with ALS
Symptoms
Symptoms include:
- Progressive weakness in arms and legs (at first often on only one side)
- Trouble holding things without dropping them
- Frequent tripping while walking
- Shrunken muscles
- Twitchy muscles
- Overactive reflexes
- Slurred speech
- Hoarseness
- Trouble chewing and swallowing, resulting in frequent choking and gagging
- Weight loss due to trouble eating
- Trouble breathing
- Excess salivation, drooling
- Severe weight loss
- Trouble coughing, resulting in development of pneumonia
Diagnosis
The doctor will ask about your symptoms and medical history, and perform a
physical exam. There are no tests that definitively diagnose ALS, but tests may
be used to rule out other medical conditions.
Tests may include:
Tests may include:
- Electromyogram (EMG) – to look for progressive muscle weakness and twitching
- CT scan - a type of x-ray that uses a computer to make pictures of the structures inside the head
- MRI scan - a test that uses magnetic waves to make pictures of the structures inside the head
- Blood tests
- Urine tests
Treatment
There are currently no cures for ALS. A new drug called riluzole is being
studied. It may slightly improve functioning for ALS patients, although it
doesn't stop the disease progression. Another drug, mecasermin is also being
researched.
Treatments for the symptoms of ALS include:
Valium, baclofen, or dantrolene - to reduce spasticity
Nonsteroidal anti-inflammatory drugs (such as ibuprofen) and anti-seizure medications - to reduce pain from muscle cramping
Physical therapy – to reduce pain associated with muscle cramping and spasticity
Atropine, scopolamine, or an antihistamine – to reduce heavy drooling
Antidepressants, anxiolytic drugs, and psychotherapy – to treat depression and anxiety
Treatments for the symptoms of ALS include:
Valium, baclofen, or dantrolene - to reduce spasticity
Nonsteroidal anti-inflammatory drugs (such as ibuprofen) and anti-seizure medications - to reduce pain from muscle cramping
Physical therapy – to reduce pain associated with muscle cramping and spasticity
Atropine, scopolamine, or an antihistamine – to reduce heavy drooling
Antidepressants, anxiolytic drugs, and psychotherapy – to treat depression and anxiety