Are antidepressants keeping your sex life down?

How antidepressants can cause sexual side effects

Kanaris says that there are two basic sexual side effects that are caused by SSRIs: delayed ejaculation and absent or delayed orgasm.

"It is also very common to hear from patients that desire is affected," he says. "Arousal problems are frequently reported, although an actual drop in libido hasn't been scientifically proven."

"A lot of doctors don't explain to their patients that these are possible side effects," sighs Modell. "These side effects can cause one partner in a relationship to have a complete loss of libido, which then starts them wondering about whether they still love their spouse. They continue to believe there is something wrong with them?[or more importantly, with their relationship]?until their doctor tells them it's a common side effect."

Kanaris agrees. "I usually spend a significant amount of time educating my patients [who take SSRIs] about sexual dysfunction, and emphasize that it is caused by the medication, not any ill will on the part of the person suffering from the symptoms."

Kanaris and Modell agree that sexual dysfunction is a problem that should be treated very seriously by the psychiatrist or physician who prescribes the SSRI.

"As a profession, we have underestimated the importance of a healthy sexual life on the general life, the healthy life, of the whole person. Sex is very important in the scheme of things," stresses Kanaris. "These patients are already battling depression?they don't need the added burden of sexual dysfunction," says Modell.

Treatment options

Modell has spent years researching the sexual side effects caused by SSRIs. His studies show that there are several treatment options for people suffering from SSRI-induced sexual dysfunction. He first suggests Wellbutrin SR (an antidepressant, but not an SSRI) as an alternate medication for depression.

"Wellbutrin SR is a good drug for depression, and I don't think doctors use it nearly enough," he says. Modell's studies have shown that Wellbutrin SR can reverse the sexual side effects caused by SSRIs, when taken in combination with the SSRI or when used as alternative therapy.

"Patients may find that they can take Wellbutrin SR for a significant amount of their depression treatment, and reduce the amount of the SSRI," he suggests. He points out that Wellbutrin SR is known to enhance arousal and orgasm in both depressed and non-depressed persons.

"Some method of treatment with Wellbutrin SR would be my first choice for treatment," he says.

He emphasizes, however, that the heightened sexual response with Wellbutrin is modest and that the drug has not been tested?nor should it be used?solely for sexual problems.

Modell also points to other antidepressant options such as Effexor, which is thought to cause sexual side effects in only 20% of patients. Remeron is also good, according to Modell, but it can cause sleepiness or weight gain, both of which might contribute to sexual dysfunction separately. He also suggests that some patients may find relief by taking Serzone, which is not thought to cause sexual side effects, but may cause sleepiness or upset stomach.

H. George Nurnberg, MD, professor of psychiatry at the University of New Mexico, reports that small-scale studies show Viagra to be effective at treating sexual dysfunction in both women and men who take antidepressants. He cautions that the mechanism for Viagra's encouraging results is unknown, but says the outlook is good. He also feels that effective treatments for sexual dysfunction in people who take SSRIs are especially important, because 60% of patients being treated with an SSRI discontinue its use after three to four months because of the sexual side effects.

A "drug holiday"

Kanaris suggests other treatment options if the aforementioned medications don't do the trick.

"I advise my patients to wait a while before switching medications. Sometimes a tolerance develops, and the sexual side effects disappear." He also says that a reduced dosage of the SSRI can be effective, or the patient can take a "drug holiday."

Pioneered by Dr. Anthony Rothschild, of the McLean Hospital in Belmont, Massachusetts, a drug holiday typically works as follows: patients stop taking the SSRI on Thursday morning, and resume taking it on Sunday afternoon, hopefully finding themselves without the sexual side effects for the weekend. Kanaris and Rothschild caution, however, that this method can have debilitating side effects if patients forget to resume the medication.

Ongoing research

Dr. Alan J. Cohen, MD, Assistant Clinical Professor of Psychiatry at the University of California in San Francisco, recently published a study that shows a link between low free testosterone levels and the sexual dysfunction caused by SSRIs. This study was very small, however, and more research needs to be done to determine what role this may play in sexual dysfunction.

Other studies have shown limited success of using ginkgo extract to relieve sexual side effects, but Dr. Modell says that he hasn't seen any really promising data. "Ginkgo can cause side effects and drug interactions with medications the patient is already taking, and it can be impure or unreliable. I don't suggest it as a treatment option."

What's the bottom line? If you take an SSRI and are suffering from sexual side effects, talk to your doctor immediately. There are options that can reduce or eliminate the side effects and put the spark back in your love life.